Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2398768..2399388 Replicon chromosome
Accession NZ_OW707734
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NBX04_RS11665 Protein ID WP_001280991.1
Coordinates 2398768..2398986 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NBX04_RS11670 Protein ID WP_000344807.1
Coordinates 2399014..2399388 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBX04_RS11625 2393991..2394560 + 570 WP_000779802.1 YbaY family lipoprotein -
NBX04_RS11630 2394593..2394982 - 390 WP_000961285.1 MGMT family protein -
NBX04_RS11640 2395213..2396763 - 1551 WP_000213129.1 EAL domain-containing protein -
NBX04_RS11645 2396988..2397248 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NBX04_RS11650 2397254..2397394 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NBX04_RS11655 2397450..2397920 - 471 WP_000136183.1 YlaC family protein -
NBX04_RS11660 2398038..2398589 - 552 WP_001278793.1 maltose O-acetyltransferase -
NBX04_RS11665 2398768..2398986 - 219 WP_001280991.1 HHA domain-containing protein Toxin
NBX04_RS11670 2399014..2399388 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NBX04_RS11675 2399884..2403033 - 3150 WP_001132507.1 efflux RND transporter permease AcrB -
NBX04_RS11680 2403056..2404249 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T295509 WP_001280991.1 NZ_OW707734:c2398986-2398768 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT295509 WP_000344807.1 NZ_OW707734:c2399388-2399014 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References