Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1974498..1975312 Replicon chromosome
Accession NZ_OW707734
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NBX04_RS09585 Protein ID WP_000971655.1
Coordinates 1974498..1975025 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NBX04_RS09590 Protein ID WP_000855694.1
Coordinates 1975022..1975312 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBX04_RS09565 1969706..1972273 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
NBX04_RS09570 1972431..1972951 + 521 Protein_1861 cytoplasmic protein -
NBX04_RS09575 1973121..1973777 - 657 WP_000420463.1 protein-serine/threonine phosphatase -
NBX04_RS09580 1974004..1974425 + 422 Protein_1863 IS5/IS1182 family transposase -
NBX04_RS09585 1974498..1975025 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NBX04_RS09590 1975022..1975312 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NBX04_RS09595 1975582..1975782 - 201 Protein_1866 transposase -
NBX04_RS09600 1976186..1976629 - 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NBX04_RS09605 1977085..1977735 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
NBX04_RS09610 1977732..1979420 + 1689 WP_000848103.1 type III secretion system outer membrane ring protein InvG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 1974279..1983048 8769
- flank IS/Tn - - 1974279..1974425 146


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T295508 WP_000971655.1 NZ_OW707734:c1975025-1974498 [Salmonella enterica subsp. enterica serovar Typhi]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT295508 WP_000855694.1 NZ_OW707734:c1975312-1975022 [Salmonella enterica subsp. enterica serovar Typhi]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References