Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1820953..1821578 Replicon chromosome
Accession NZ_OW707734
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NBX04_RS08875 Protein ID WP_000911334.1
Coordinates 1821180..1821578 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NBX04_RS08870 Protein ID WP_000557549.1
Coordinates 1820953..1821180 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBX04_RS08840 1816124..1816843 + 720 WP_000082599.1 Rha family transcriptional regulator -
NBX04_RS08845 1816847..1817050 + 204 WP_000184036.1 hypothetical protein -
NBX04_RS08850 1817133..1817588 + 456 WP_223229661.1 hypothetical protein -
NBX04_RS08855 1817690..1818811 + 1122 WP_000028980.1 hypothetical protein -
NBX04_RS08860 1819444..1820250 - 807 WP_077905073.1 DUF1460 domain-containing protein -
NBX04_RS08865 1820525..1820776 - 252 WP_001540858.1 hypothetical protein -
NBX04_RS08870 1820953..1821180 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NBX04_RS08875 1821180..1821578 + 399 WP_000911334.1 tRNA(fMet)-specific endonuclease VapC Toxin
NBX04_RS08880 1822385..1822921 + 537 WP_001038500.1 STM3031 family outer membrane protein -
NBX04_RS08885 1822968..1823600 + 633 WP_000835268.1 YfdX family protein -
NBX04_RS08890 1824319..1824900 + 582 WP_001244646.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1813872..1830023 16151


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15091.44 Da        Isoelectric Point: 7.7785

>T295507 WP_000911334.1 NZ_OW707734:1821180-1821578 [Salmonella enterica subsp. enterica serovar Typhi]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNFAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT295507 WP_000557549.1 NZ_OW707734:1820953-1821180 [Salmonella enterica subsp. enterica serovar Typhi]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References