Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 862529..863289 Replicon chromosome
Accession NZ_OW707734
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name tacT Uniprot ID Q8Z2B1
Locus tag NBX04_RS04175 Protein ID WP_000533908.1
Coordinates 862529..863014 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag NBX04_RS04180 Protein ID WP_000965889.1
Coordinates 863002..863289 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBX04_RS04145 857599..858261 + 663 WP_000747548.1 OmpA family lipoprotein -
NBX04_RS04150 858480..859454 + 975 WP_000804690.1 glyoxylate/hydroxypyruvate reductase GhrB -
NBX04_RS04155 859504..860214 - 711 WP_000190524.1 DUF3053 domain-containing protein -
NBX04_RS04160 860653..860940 + 288 Protein_817 HTH-type transcriptional regulator -
NBX04_RS04165 861231..861443 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NBX04_RS04170 861619..862158 + 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
NBX04_RS04175 862529..863014 - 486 WP_000533908.1 GNAT family N-acetyltransferase Toxin
NBX04_RS04180 863002..863289 - 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
NBX04_RS04185 863467..863934 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
NBX04_RS04190 864076..864504 - 429 Protein_823 IS3 family transposase -
NBX04_RS04195 864894..866963 - 2070 WP_001291805.1 glycine--tRNA ligase subunit beta -
NBX04_RS04200 866973..867884 - 912 WP_001168555.1 glycine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17689.38 Da        Isoelectric Point: 9.8719

>T295503 WP_000533908.1 NZ_OW707734:c863014-862529 [Salmonella enterica subsp. enterica serovar Typhi]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEDAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT295503 WP_000965889.1 NZ_OW707734:c863289-863002 [Salmonella enterica subsp. enterica serovar Typhi]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A714MHS9

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References