Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4564640..4565156 Replicon chromosome
Accession NZ_OW706648
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag NBW98_RS22485 Protein ID WP_000220578.1
Coordinates 4564872..4565156 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NBW98_RS22480 Protein ID WP_000212724.1
Coordinates 4564640..4564882 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW98_RS22460 4559660..4560793 + 1134 WP_000459938.1 amidohydrolase/deacetylase family metallohydrolase -
NBW98_RS22465 4560777..4561895 + 1119 WP_001139189.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NBW98_RS22470 4561892..4562632 + 741 WP_000779260.1 KDGP aldolase family protein -
NBW98_RS22475 4562649..4564562 + 1914 WP_250279043.1 BglG family transcription antiterminator -
NBW98_RS22480 4564640..4564882 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBW98_RS22485 4564872..4565156 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBW98_RS22490 4565160..4565624 - 465 WP_001268860.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NBW98_RS22495 4565745..4567883 - 2139 WP_000187820.1 anaerobic ribonucleoside-triphosphate reductase -
NBW98_RS22500 4568292..4569944 - 1653 WP_000155051.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T295497 WP_000220578.1 NZ_OW706648:4564872-4565156 [Salmonella enterica subsp. enterica serovar Typhi]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT295497 WP_000212724.1 NZ_OW706648:4564640-4564882 [Salmonella enterica subsp. enterica serovar Typhi]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References