Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4447258..4448036 Replicon chromosome
Accession NZ_OW706648
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1C2
Locus tag NBW98_RS21865 Protein ID WP_000622308.1
Coordinates 4447548..4448036 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1C3
Locus tag NBW98_RS21860 Protein ID WP_001143724.1
Coordinates 4447258..4447551 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW98_RS21845 4442570..4444081 + 1512 WP_001120833.1 UvrD-helicase domain-containing protein -
NBW98_RS21850 4444065..4445654 + 1590 WP_000488995.1 TraI domain-containing protein -
NBW98_RS21855 4445818..4446831 + 1014 WP_000449622.1 site-specific integrase -
NBW98_RS21860 4447258..4447551 + 294 WP_001143724.1 DUF1778 domain-containing protein Antitoxin
NBW98_RS21865 4447548..4448036 + 489 WP_000622308.1 GNAT family N-acetyltransferase Toxin
NBW98_RS21870 4448216..4448668 - 453 WP_000434168.1 hypothetical protein -
NBW98_RS21875 4448750..4449001 - 252 WP_024131240.1 hypothetical protein -
NBW98_RS21880 4449305..4451590 - 2286 WP_010989300.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - sopE2 / vexE / vexD / vexC / vexB / vexA / tviE / tviD / tviC / tviB 4186358..4450572 264214


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17538.36 Da        Isoelectric Point: 7.3252

>T295496 WP_000622308.1 NZ_OW706648:4447548-4448036 [Salmonella enterica subsp. enterica serovar Typhi]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVTGASRTFVCCGSDSDVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA

Download         Length: 489 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10906.59 Da        Isoelectric Point: 6.3493

>AT295496 WP_001143724.1 NZ_OW706648:4447258-4447551 [Salmonella enterica subsp. enterica serovar Typhi]
MPVANSMAMKRETLNLRIKPAERDLIDRAAKARGKNCTDFVLEAARAAAEEALIEQRIIMADPEAYQAFLIRLDQAPAPN
DALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A716G941

Antitoxin

Source ID Structure
AlphaFold DB A0A716D9M3

References