Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3914749..3915509 Replicon chromosome
Accession NZ_OW706648
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name tacT Uniprot ID Q8Z2B1
Locus tag NBW98_RS19365 Protein ID WP_000533908.1
Coordinates 3914749..3915234 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag NBW98_RS19370 Protein ID WP_000965889.1
Coordinates 3915222..3915509 (-) Length 96 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW98_RS19335 3909819..3910481 + 663 WP_000747548.1 OmpA family lipoprotein -
NBW98_RS19340 3910700..3911674 + 975 WP_000804690.1 glyoxylate/hydroxypyruvate reductase GhrB -
NBW98_RS19345 3911724..3912434 - 711 WP_000190524.1 DUF3053 domain-containing protein -
NBW98_RS19350 3912873..3913160 + 288 Protein_3769 HTH-type transcriptional regulator -
NBW98_RS19355 3913451..3913663 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NBW98_RS19360 3913839..3914378 + 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
NBW98_RS19365 3914749..3915234 - 486 WP_000533908.1 GNAT family N-acetyltransferase Toxin
NBW98_RS19370 3915222..3915509 - 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
NBW98_RS19375 3915687..3916154 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
NBW98_RS19380 3916296..3916724 - 429 Protein_3775 IS3 family transposase -
NBW98_RS19385 3917114..3919183 - 2070 WP_001291805.1 glycine--tRNA ligase subunit beta -
NBW98_RS19390 3919193..3920104 - 912 WP_001168555.1 glycine--tRNA ligase subunit alpha -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(31-152)

Antitoxin

(13-89)


Sequences


Toxin        


Download         Length: 162 a.a.        Molecular weight: 17689.38 Da        Isoelectric Point: 9.8719

>T295494 WP_000533908.1 NZ_OW706648:c3915234-3914749 [Salmonella enterica subsp. enterica serovar Typhi]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEDAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp


Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT295494 WP_000965889.1 NZ_OW706648:c3915509-3915222 [Salmonella enterica subsp. enterica serovar Typhi]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A714MHS9


Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References