Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 3914749..3915509 | Replicon | chromosome |
Accession | NZ_OW706648 | ||
Organism | Salmonella enterica subsp. enterica serovar Typhi strain BRD948 |
Toxin (Protein)
Gene name | tacT | Uniprot ID | Q8Z2B1 |
Locus tag | NBW98_RS19365 | Protein ID | WP_000533908.1 |
Coordinates | 3914749..3915234 (-) | Length | 162 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | Q8Z2B2 |
Locus tag | NBW98_RS19370 | Protein ID | WP_000965889.1 |
Coordinates | 3915222..3915509 (-) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NBW98_RS19335 | 3909819..3910481 | + | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
NBW98_RS19340 | 3910700..3911674 | + | 975 | WP_000804690.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
NBW98_RS19345 | 3911724..3912434 | - | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
NBW98_RS19350 | 3912873..3913160 | + | 288 | Protein_3769 | HTH-type transcriptional regulator | - |
NBW98_RS19355 | 3913451..3913663 | + | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
NBW98_RS19360 | 3913839..3914378 | + | 540 | WP_000047148.1 | copper-binding periplasmic metallochaperone CueP | - |
NBW98_RS19365 | 3914749..3915234 | - | 486 | WP_000533908.1 | GNAT family N-acetyltransferase | Toxin |
NBW98_RS19370 | 3915222..3915509 | - | 288 | WP_000965889.1 | DUF1778 domain-containing protein | Antitoxin |
NBW98_RS19375 | 3915687..3916154 | - | 468 | WP_000702452.1 | GNAT family N-acetyltransferase | - |
NBW98_RS19380 | 3916296..3916724 | - | 429 | Protein_3775 | IS3 family transposase | - |
NBW98_RS19385 | 3917114..3919183 | - | 2070 | WP_001291805.1 | glycine--tRNA ligase subunit beta | - |
NBW98_RS19390 | 3919193..3920104 | - | 912 | WP_001168555.1 | glycine--tRNA ligase subunit alpha | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17689.38 Da Isoelectric Point: 9.8719
>T295494 WP_000533908.1 NZ_OW706648:c3915234-3914749 [Salmonella enterica subsp. enterica serovar Typhi]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEDAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEDAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
Antitoxin
Download Length: 96 a.a. Molecular weight: 10964.59 Da Isoelectric Point: 4.6811
>AT295494 WP_000965889.1 NZ_OW706648:c3915509-3915222 [Salmonella enterica subsp. enterica serovar Typhi]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A714MHS9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A752RW74 |