Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3622991..3623607 Replicon chromosome
Accession NZ_OW706648
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name vapC Uniprot ID Q8Z2U3
Locus tag NBW98_RS17950 Protein ID WP_000238494.1
Coordinates 3622991..3623365 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E9YHE9
Locus tag NBW98_RS17955 Protein ID WP_001523745.1
Coordinates 3623365..3623607 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW98_RS17935 3620493..3621395 + 903 WP_000331359.1 formate dehydrogenase subunit beta -
NBW98_RS17940 3621392..3622027 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NBW98_RS17945 3622024..3622953 + 930 WP_000027727.1 formate dehydrogenase accessory protein FdhE -
NBW98_RS17950 3622991..3623365 - 375 WP_000238494.1 type II toxin-antitoxin system VapC family toxin Toxin
NBW98_RS17955 3623365..3623607 - 243 WP_001523745.1 CopG family transcriptional regulator Antitoxin
NBW98_RS17960 3623812..3624741 + 930 WP_001162859.1 alpha/beta hydrolase -
NBW98_RS17965 3624827..3625138 + 312 WP_000558160.1 type II toxin-antitoxin system HigB family toxin -
NBW98_RS17970 3625135..3625581 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
NBW98_RS17975 3625596..3626537 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NBW98_RS17980 3626582..3627019 - 438 WP_000560975.1 D-aminoacyl-tRNA deacylase -
NBW98_RS17985 3627016..3627888 - 873 WP_000921423.1 virulence factor BrkB family protein -
NBW98_RS17990 3627882..3628481 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13908.18 Da        Isoelectric Point: 7.3567

>T295492 WP_000238494.1 NZ_OW706648:c3623365-3622991 [Salmonella enterica subsp. enterica serovar Typhi]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9437.77 Da        Isoelectric Point: 4.4463

>AT295492 WP_001523745.1 NZ_OW706648:c3623607-3623365 [Salmonella enterica subsp. enterica serovar Typhi]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CND8

Antitoxin

Source ID Structure

References