Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3640824..3641503 Replicon chromosome
Accession NC_021500
Organism Enterobacter sp. R4-368

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag H650_RS17090 Protein ID WP_032608412.1
Coordinates 3641162..3641503 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag H650_RS17085 Protein ID WP_020456353.1
Coordinates 3640824..3641141 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H650_RS17050 3636114..3636938 + 825 WP_020456345.1 DUF945 domain-containing protein -
H650_RS17055 3637147..3637830 + 684 WP_020456346.1 DeoR family transcriptional regulator -
H650_RS17060 3638069..3638935 + 867 WP_020456348.1 hypothetical protein -
H650_RS24795 3639062..3639262 + 201 WP_110093642.1 DUF905 family protein -
H650_RS17065 3639368..3639826 + 459 WP_020456349.1 antirestriction protein -
H650_RS17070 3639836..3640054 + 219 WP_020456350.1 hypothetical protein -
H650_RS17075 3640097..3640576 + 480 WP_020456351.1 DNA repair protein RadC -
H650_RS17080 3640585..3640806 + 222 WP_032608411.1 DUF987 domain-containing protein -
H650_RS17085 3640824..3641141 + 318 WP_020456353.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H650_RS17090 3641162..3641503 + 342 WP_032608412.1 TA system toxin CbtA family protein Toxin
H650_RS17095 3641744..3642751 + 1008 WP_020456355.1 restriction endonuclease -
H650_RS17100 3643134..3644390 + 1257 WP_020456356.1 integrase arm-type DNA-binding domain-containing protein -
H650_RS17105 3644878..3646002 - 1125 WP_020456357.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3617387..3661634 44247


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12747.73 Da        Isoelectric Point: 9.0060

>T29549 WP_032608412.1 NC_021500:3641162-3641503 [Enterobacter sp. R4-368]
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

>T29549 NC_021500:3641162-3641503 [Enterobacter sp. R4-368]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
AACTGGCAAGAACAGTCCCCATATCTGCGGGCGGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11846.39 Da        Isoelectric Point: 5.5403

>AT29549 WP_020456353.1 NC_021500:3640824-3641141 [Enterobacter sp. R4-368]
MSNTTWGLQRDITPRLGARLVQEGNWLHYLADRASITGKFSEAECLKLDVVFPNFISQLESMLTTGEMNPSHAYCVTLYH
NGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 318 bp

>AT29549 NC_021500:3640824-3641141 [Enterobacter sp. R4-368]
ATGAGCAACACCACATGGGGACTGCAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGGTTCAGGAGGGCAACTGGCT
GCACTATTTGGCTGACCGAGCCAGTATTACCGGTAAATTCAGCGAAGCAGAATGTCTTAAGCTGGATGTGGTATTTCCGA
ATTTTATCAGCCAGTTGGAGTCAATGCTTACCACTGGTGAAATGAACCCTAGCCATGCCTATTGTGTCACCCTGTACCAC
AATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGCCGTTTACCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References