Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2393741..2394361 Replicon chromosome
Accession NZ_OW706648
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NBW98_RS11880 Protein ID WP_001280991.1
Coordinates 2394143..2394361 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NBW98_RS11875 Protein ID WP_000344807.1
Coordinates 2393741..2394115 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW98_RS11865 2388880..2390073 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NBW98_RS11870 2390096..2393245 + 3150 WP_001132507.1 efflux RND transporter permease AcrB -
NBW98_RS11875 2393741..2394115 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NBW98_RS11880 2394143..2394361 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NBW98_RS11885 2394540..2395091 + 552 WP_001278793.1 maltose O-acetyltransferase -
NBW98_RS11890 2395209..2395679 + 471 WP_000136183.1 YlaC family protein -
NBW98_RS11895 2395735..2395875 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NBW98_RS11900 2395881..2396141 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NBW98_RS11905 2396366..2397916 + 1551 WP_000213129.1 EAL domain-containing protein -
NBW98_RS11915 2398147..2398536 + 390 WP_000961285.1 MGMT family protein -
NBW98_RS11920 2398569..2399138 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T295488 WP_001280991.1 NZ_OW706648:2394143-2394361 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT295488 WP_000344807.1 NZ_OW706648:2393741-2394115 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References