Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4038881..4039457 Replicon chromosome
Accession NZ_OW706512
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag NBW89_RS20150 Protein ID WP_001131963.1
Coordinates 4038881..4039168 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag NBW89_RS20155 Protein ID WP_000063142.1
Coordinates 4039155..4039457 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW89_RS20140 4034007..4037516 - 3510 WP_001043493.1 type I restriction-modification system endonuclease -
NBW89_RS20145 4037714..4038628 + 915 WP_000290515.1 restriction endonuclease -
NBW89_RS20150 4038881..4039168 + 288 WP_001131963.1 BrnT family toxin Toxin
NBW89_RS20155 4039155..4039457 + 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
NBW89_RS20160 4039532..4040488 - 957 WP_000187846.1 GTPase -
NBW89_RS20165 4040499..4040702 - 204 WP_000460616.1 YbdD/YjiX family protein -
NBW89_RS20170 4040797..4042947 - 2151 WP_000379928.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T295483 WP_001131963.1 NZ_OW706512:4038881-4039168 [Salmonella enterica subsp. enterica serovar Typhi]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT295483 WP_000063142.1 NZ_OW706512:4039155-4039457 [Salmonella enterica subsp. enterica serovar Typhi]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References