Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3936363..3936879 Replicon chromosome
Accession NZ_OW706512
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag NBW89_RS19680 Protein ID WP_000220578.1
Coordinates 3936595..3936879 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NBW89_RS19675 Protein ID WP_000212724.1
Coordinates 3936363..3936605 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW89_RS19655 3931383..3932516 + 1134 WP_000459938.1 amidohydrolase/deacetylase family metallohydrolase -
NBW89_RS19660 3932500..3933618 + 1119 WP_001139189.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NBW89_RS19665 3933615..3934355 + 741 WP_000779260.1 KDGP aldolase family protein -
NBW89_RS19670 3934372..3936285 + 1914 WP_250279043.1 BglG family transcription antiterminator -
NBW89_RS19675 3936363..3936605 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBW89_RS19680 3936595..3936879 + 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBW89_RS19685 3936883..3937347 - 465 WP_001268860.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NBW89_RS19690 3937468..3939606 - 2139 WP_000187820.1 anaerobic ribonucleoside-triphosphate reductase -
NBW89_RS19695 3940015..3941667 - 1653 WP_000155051.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T295482 WP_000220578.1 NZ_OW706512:3936595-3936879 [Salmonella enterica subsp. enterica serovar Typhi]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT295482 WP_000212724.1 NZ_OW706512:3936363-3936605 [Salmonella enterica subsp. enterica serovar Typhi]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References