Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3818981..3819759 Replicon chromosome
Accession NZ_OW706512
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1C2
Locus tag NBW89_RS19060 Protein ID WP_000622308.1
Coordinates 3819271..3819759 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1C3
Locus tag NBW89_RS19055 Protein ID WP_001143724.1
Coordinates 3818981..3819274 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW89_RS19040 3814293..3815804 + 1512 WP_001120833.1 UvrD-helicase domain-containing protein -
NBW89_RS19045 3815788..3817377 + 1590 WP_000488995.1 TraI domain-containing protein -
NBW89_RS19050 3817541..3818554 + 1014 WP_000449622.1 site-specific integrase -
NBW89_RS19055 3818981..3819274 + 294 WP_001143724.1 DUF1778 domain-containing protein Antitoxin
NBW89_RS19060 3819271..3819759 + 489 WP_000622308.1 GNAT family N-acetyltransferase Toxin
NBW89_RS19065 3819939..3820391 - 453 WP_000434168.1 hypothetical protein -
NBW89_RS19070 3820473..3820724 - 252 WP_024131240.1 hypothetical protein -
NBW89_RS19075 3821028..3823313 - 2286 WP_010989300.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - sopE2 / vexE / vexD / vexC / vexB / vexA / tviE / tviD / tviC / tviB 3558081..3822295 264214


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17538.36 Da        Isoelectric Point: 7.3252

>T295481 WP_000622308.1 NZ_OW706512:3819271-3819759 [Salmonella enterica subsp. enterica serovar Typhi]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVTGASRTFVCCGSDSDVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA

Download         Length: 489 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10906.59 Da        Isoelectric Point: 6.3493

>AT295481 WP_001143724.1 NZ_OW706512:3818981-3819274 [Salmonella enterica subsp. enterica serovar Typhi]
MPVANSMAMKRETLNLRIKPAERDLIDRAAKARGKNCTDFVLEAARAAAEEALIEQRIIMADPEAYQAFLIRLDQAPAPN
DALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A716G941

Antitoxin

Source ID Structure
AlphaFold DB A0A716D9M3

References