Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3697634..3698415 Replicon chromosome
Accession NZ_OW706512
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1M4
Locus tag NBW89_RS18360 Protein ID WP_000626103.1
Coordinates 3697924..3698415 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1M5
Locus tag NBW89_RS18355 Protein ID WP_001110456.1
Coordinates 3697634..3697927 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW89_RS18325 3693887..3694792 + 906 WP_001268195.1 YjiK family protein -
NBW89_RS18330 3695079..3695423 - 345 WP_100680417.1 Ig-like domain-containing protein -
NBW89_RS18335 3695431..3695647 - 217 Protein_3574 hypothetical protein -
NBW89_RS18340 3695670..3695957 - 288 WP_001269916.1 transcriptional regulator RtsB -
NBW89_RS18345 3695954..3696829 - 876 WP_000921674.1 AraC family transcriptional regulator -
NBW89_RS18350 3697095..3697317 - 223 Protein_3577 hypothetical protein -
NBW89_RS18355 3697634..3697927 + 294 WP_001110456.1 DUF1778 domain-containing protein Antitoxin
NBW89_RS18360 3697924..3698415 + 492 WP_000626103.1 GNAT family N-acetyltransferase Toxin
NBW89_RS18365 3698656..3699408 - 753 WP_001785756.1 non-specific acid phosphatase -
NBW89_RS18370 3699508..3699585 - 78 Protein_3581 porin family protein -
NBW89_RS18375 3699965..3700039 + 75 Protein_3582 helix-turn-helix domain-containing protein -
NBW89_RS18380 3700253..3701287 + 1035 WP_001195363.1 ParA family protein -
NBW89_RS18385 3701284..3702648 + 1365 WP_000018529.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - sopE2 / vexE / vexD / vexC / vexB / vexA / tviE / tviD / tviC / tviB 3558081..3822295 264214


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17675.47 Da        Isoelectric Point: 7.2652

>T295480 WP_000626103.1 NZ_OW706512:3697924-3698415 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T295480 NZ_OW706512:3697924-3698415 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGTGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11005.67 Da        Isoelectric Point: 8.6141

>AT295480 WP_001110456.1 NZ_OW706512:3697634-3697927 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT295480 NZ_OW706512:3697634-3697927 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGTGAAACTCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGTTGGAAGCTGCCCGTGCTGCCGCAGAAGAAGTGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAATTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A718CB38

Antitoxin

Source ID Structure
AlphaFold DB A0A716NSU2

References