Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3301380..3302140 Replicon chromosome
Accession NZ_OW706512
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name tacT Uniprot ID Q8Z2B1
Locus tag NBW89_RS16575 Protein ID WP_000533908.1
Coordinates 3301655..3302140 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag NBW89_RS16570 Protein ID WP_000965889.1
Coordinates 3301380..3301667 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW89_RS16550 3296785..3297696 + 912 WP_001168555.1 glycine--tRNA ligase subunit alpha -
NBW89_RS16555 3297706..3299775 + 2070 WP_001291805.1 glycine--tRNA ligase subunit beta -
NBW89_RS16560 3300165..3300593 + 429 Protein_3225 IS3 family transposase -
NBW89_RS16565 3300735..3301202 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
NBW89_RS16570 3301380..3301667 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
NBW89_RS16575 3301655..3302140 + 486 WP_000533908.1 GNAT family N-acetyltransferase Toxin
NBW89_RS16580 3302511..3303050 - 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
NBW89_RS16585 3303226..3303438 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NBW89_RS16590 3303729..3304016 - 288 Protein_3231 HTH-type transcriptional regulator -
NBW89_RS16595 3304455..3305165 + 711 WP_000190524.1 DUF3053 domain-containing protein -
NBW89_RS16600 3305215..3306189 - 975 WP_000804690.1 glyoxylate/hydroxypyruvate reductase GhrB -
NBW89_RS16605 3306408..3307070 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17689.38 Da        Isoelectric Point: 9.8719

>T295479 WP_000533908.1 NZ_OW706512:3301655-3302140 [Salmonella enterica subsp. enterica serovar Typhi]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEDAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT295479 WP_000965889.1 NZ_OW706512:3301380-3301667 [Salmonella enterica subsp. enterica serovar Typhi]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A714MHS9

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References