Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2343248..2343873 Replicon chromosome
Accession NZ_OW706512
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NBW89_RS11865 Protein ID WP_000911334.1
Coordinates 2343248..2343646 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NBW89_RS11870 Protein ID WP_000557549.1
Coordinates 2343646..2343873 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW89_RS11850 2339926..2340507 - 582 WP_001244646.1 fimbrial protein -
NBW89_RS11855 2341226..2341858 - 633 WP_000835268.1 YfdX family protein -
NBW89_RS11860 2341905..2342441 - 537 WP_001038500.1 STM3031 family outer membrane protein -
NBW89_RS11865 2343248..2343646 - 399 WP_000911334.1 tRNA(fMet)-specific endonuclease VapC Toxin
NBW89_RS11870 2343646..2343873 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NBW89_RS11875 2344050..2344301 + 252 WP_001540858.1 hypothetical protein -
NBW89_RS11880 2344576..2345382 + 807 WP_077905073.1 DUF1460 domain-containing protein -
NBW89_RS11885 2346015..2347136 - 1122 WP_000028980.1 hypothetical protein -
NBW89_RS11890 2347238..2347693 - 456 WP_223229661.1 hypothetical protein -
NBW89_RS11895 2347776..2347979 - 204 WP_000184036.1 hypothetical protein -
NBW89_RS11900 2347983..2348702 - 720 WP_000082599.1 Rha family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2334058..2350954 16896


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15091.44 Da        Isoelectric Point: 7.7785

>T295475 WP_000911334.1 NZ_OW706512:c2343646-2343248 [Salmonella enterica subsp. enterica serovar Typhi]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNFAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT295475 WP_000557549.1 NZ_OW706512:c2343873-2343646 [Salmonella enterica subsp. enterica serovar Typhi]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References