Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 2189517..2190331 | Replicon | chromosome |
| Accession | NZ_OW706512 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhi strain BRD948 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | Q57KM2 |
| Locus tag | NBW89_RS11150 | Protein ID | WP_000971655.1 |
| Coordinates | 2189804..2190331 (+) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | NBW89_RS11145 | Protein ID | WP_000855694.1 |
| Coordinates | 2189517..2189807 (+) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NBW89_RS11125 | 2185409..2187097 | - | 1689 | WP_000848103.1 | type III secretion system outer membrane ring protein InvG | - |
| NBW89_RS11130 | 2187094..2187744 | - | 651 | WP_001674874.1 | type III secretion system transcriptional activator InvF | - |
| NBW89_RS11135 | 2188200..2188643 | + | 444 | WP_000715096.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| NBW89_RS11140 | 2189047..2189247 | + | 201 | Protein_2180 | transposase | - |
| NBW89_RS11145 | 2189517..2189807 | + | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| NBW89_RS11150 | 2189804..2190331 | + | 528 | WP_000971655.1 | GNAT family N-acetyltransferase | Toxin |
| NBW89_RS11155 | 2190404..2190825 | - | 422 | Protein_2183 | IS5/IS1182 family transposase | - |
| NBW89_RS11160 | 2191052..2191708 | + | 657 | WP_000420463.1 | protein-serine/threonine phosphatase | - |
| NBW89_RS11165 | 2191878..2192398 | - | 521 | Protein_2185 | cytoplasmic protein | - |
| NBW89_RS11170 | 2192556..2195123 | + | 2568 | WP_001005807.1 | DNA mismatch repair protein MutS | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2190404..2190550 | 146 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19069.91 Da Isoelectric Point: 9.6420
>T295474 WP_000971655.1 NZ_OW706512:2189804-2190331 [Salmonella enterica subsp. enterica serovar Typhi]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT295474 WP_000855694.1 NZ_OW706512:2189517-2189807 [Salmonella enterica subsp. enterica serovar Typhi]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 6G96 | |
| PDB | 7AK9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |