Detailed information of TA system TA029547

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3104156..3104770
• Replicon: chromosome
• Accession: NC_021500
• Organism: Enterobacter sp. R4-368

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: H650_RS24690
• Protein ID: WP_071925246.1
• Coordinates: 3104156..3104347 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: H650_RS14625
• Protein ID: WP_044489769.1
• Coordinates: 3104360..3104770 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H650_RS14590	3099457..3099738	+	282	WP_020455932.1	hypothetical protein	-
H650_RS24680	3099993..3100196	+	204	WP_071925293.1	DUF4761 family protein	-
H650_RS14595	3100186..3100413	+	228	WP_020455934.1	DUF2724 domain-containing protein	-
H650_RS14600	3100511..3100720	+	210	WP_044489767.1	hypothetical protein	-
H650_RS14605	3100761..3100958	+	198	WP_189660069.1	DUF2732 family protein	-
H650_RS14610	3101146..3101388	+	243	WP_020455937.1	hypothetical protein	-
H650_RS14615	3101391..3103769	+	2379	WP_020455938.1	replication endonuclease	-
H650_RS25340	3103802..3104068	+	267	Protein_2908	ASCH domain-containing protein	-
H650_RS24690	3104156..3104347	+	192	WP_071925246.1	type II toxin-antitoxin system HicA family toxin	Toxin
H650_RS14625	3104360..3104770	+	411	WP_044489769.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H650_RS14630	3105520..3105843	+	324	WP_020455939.1	phage holin family protein	-
H650_RS14635	3105833..3106225	+	393	WP_020455940.1	M15 family metallopeptidase	-
H650_RS14640	3106225..3106758	+	534	WP_020455941.1	DUF2514 family protein	-
H650_RS14645	3106768..3106953	+	186	WP_020455942.1	hypothetical protein	-
H650_RS24700	3107248..3107487	+	240	WP_071925247.1	ogr/Delta-like zinc finger family protein	-
H650_RS14650	3107586..3107918	+	333	WP_044489538.1	zinc ribbon domain-containing protein	-
H650_RS14655	3107929..3108549	+	621	WP_020455945.1	hypothetical protein	-
H650_RS14660	3108796..3109680	+	885	WP_020455946.1	CDF family cation-efflux transporter FieF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3096447..3107487	11040

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 6879.10 Da
• Isoelectric Point: 11.3940

>T29547 WP_071925246.1 NC_021500:3104156-3104347 [Enterobacter sp. R4-368]
MNSRKLIAEIQADGWVLVRVTGSHHHFVHPTKPGLVTIPHPKKDLPIGTVKSIRKQAGIQPAA

Nucleotide

• Length: 192 bp

>T29547 NC_021500:3104156-3104347 [Enterobacter sp. R4-368]
ATGAACAGCAGGAAGCTGATAGCAGAAATTCAGGCGGATGGGTGGGTGCTGGTAAGAGTAACAGGCAGTCATCACCACTT
CGTCCATCCAACAAAACCGGGGCTTGTGACGATACCCCATCCTAAAAAAGATTTACCGATTGGCACGGTAAAAAGCATAC
GAAAACAGGCGGGCATCCAGCCCGCCGCATGA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14859.85 Da
• Isoelectric Point: 4.9285

>AT29547 WP_044489769.1 NC_021500:3104360-3104770 [Enterobacter sp. R4-368]
MYYPIAIEAGDESHAYGVTVPDLPGCFSAGDTLDEAIKNAKEAIIGHIETLVELGHDVPSVSTAEKWSKNPAFAGYTWAL
VDIDVTRLLGGSEKINVTLPRFLIDRIDRYVATHPEYKTRSGFLAQAALERIAGIR

Nucleotide

• Length: 411 bp

>AT29547 NC_021500:3104360-3104770 [Enterobacter sp. R4-368]
ATGTATTATCCAATCGCAATCGAGGCCGGCGACGAAAGTCACGCTTACGGTGTGACAGTGCCGGATCTGCCTGGCTGCTT
TAGCGCGGGCGATACGCTTGATGAGGCGATCAAGAACGCGAAAGAGGCGATCATCGGGCATATAGAAACGCTGGTCGAGC
TGGGTCACGATGTTCCATCGGTTTCCACCGCGGAAAAGTGGTCAAAAAATCCAGCGTTTGCCGGGTATACGTGGGCGCTT
GTCGATATTGATGTGACTCGCCTGCTGGGCGGTTCCGAAAAAATCAACGTGACGCTGCCGCGCTTTCTGATCGACAGAAT
TGATCGGTACGTTGCGACACATCCGGAGTACAAAACCCGCAGCGGGTTTCTGGCGCAGGCGGCTTTAGAGAGAATCGCAG
GCATCAGATAA