Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4542383..4543003 Replicon chromosome
Accession NZ_OW704627
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NBW95_RS22310 Protein ID WP_001280991.1
Coordinates 4542785..4543003 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NBW95_RS22305 Protein ID WP_000344807.1
Coordinates 4542383..4542757 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW95_RS22295 4537522..4538715 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NBW95_RS22300 4538738..4541887 + 3150 WP_001132507.1 efflux RND transporter permease AcrB -
NBW95_RS22305 4542383..4542757 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NBW95_RS22310 4542785..4543003 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NBW95_RS22315 4543182..4543733 + 552 WP_001278793.1 maltose O-acetyltransferase -
NBW95_RS22320 4543851..4544321 + 471 WP_000136183.1 YlaC family protein -
NBW95_RS22325 4544377..4544517 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NBW95_RS22330 4544523..4544783 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NBW95_RS22335 4545008..4546558 + 1551 WP_000213129.1 EAL domain-containing protein -
NBW95_RS22345 4546789..4547178 + 390 WP_000961285.1 MGMT family protein -
NBW95_RS22350 4547211..4547780 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T295468 WP_001280991.1 NZ_OW704627:4542785-4543003 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT295468 WP_000344807.1 NZ_OW704627:4542383-4542757 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References