Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1819844..1820622 Replicon chromosome
Accession NZ_OW704627
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1C2
Locus tag NBW95_RS08840 Protein ID WP_000622308.1
Coordinates 1820134..1820622 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1C3
Locus tag NBW95_RS08835 Protein ID WP_001143724.1
Coordinates 1819844..1820137 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW95_RS08820 1815156..1816667 + 1512 WP_001120833.1 UvrD-helicase domain-containing protein -
NBW95_RS08825 1816651..1818240 + 1590 WP_000488995.1 TraI domain-containing protein -
NBW95_RS08830 1818404..1819417 + 1014 WP_000449622.1 site-specific integrase -
NBW95_RS08835 1819844..1820137 + 294 WP_001143724.1 DUF1778 domain-containing protein Antitoxin
NBW95_RS08840 1820134..1820622 + 489 WP_000622308.1 GNAT family N-acetyltransferase Toxin
NBW95_RS08845 1820802..1821254 - 453 WP_000434168.1 hypothetical protein -
NBW95_RS08850 1821336..1821587 - 252 WP_024131240.1 hypothetical protein -
NBW95_RS08855 1821891..1824176 - 2286 WP_010989300.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - sopE2 / vexE / vexD / vexC / vexB / vexA / tviE / tviD / tviC / tviB 1558942..1823158 264216


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17538.36 Da        Isoelectric Point: 7.3252

>T295461 WP_000622308.1 NZ_OW704627:1820134-1820622 [Salmonella enterica subsp. enterica serovar Typhi]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVTGASRTFVCCGSDSDVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA

Download         Length: 489 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10906.59 Da        Isoelectric Point: 6.3493

>AT295461 WP_001143724.1 NZ_OW704627:1819844-1820137 [Salmonella enterica subsp. enterica serovar Typhi]
MPVANSMAMKRETLNLRIKPAERDLIDRAAKARGKNCTDFVLEAARAAAEEALIEQRIIMADPEAYQAFLIRLDQAPAPN
DALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A716G941

Antitoxin

Source ID Structure
AlphaFold DB A0A716D9M3

References