Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1403109..1403725 Replicon chromosome
Accession NZ_OW704627
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name vapC Uniprot ID Q8Z2U3
Locus tag NBW95_RS06865 Protein ID WP_000238494.1
Coordinates 1403351..1403725 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E9YHE9
Locus tag NBW95_RS06860 Protein ID WP_001523745.1
Coordinates 1403109..1403351 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW95_RS06825 1398235..1398834 + 600 WP_000965695.1 glucose-1-phosphatase -
NBW95_RS06830 1398828..1399700 + 873 WP_000921423.1 virulence factor BrkB family protein -
NBW95_RS06835 1399697..1400134 + 438 WP_000560975.1 D-aminoacyl-tRNA deacylase -
NBW95_RS06840 1400179..1401120 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NBW95_RS06845 1401135..1401581 - 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
NBW95_RS06850 1401578..1401889 - 312 WP_000558160.1 type II toxin-antitoxin system HigB family toxin -
NBW95_RS06855 1401975..1402904 - 930 WP_001162859.1 alpha/beta hydrolase -
NBW95_RS06860 1403109..1403351 + 243 WP_001523745.1 CopG family transcriptional regulator Antitoxin
NBW95_RS06865 1403351..1403725 + 375 WP_000238494.1 type II toxin-antitoxin system VapC family toxin Toxin
NBW95_RS06870 1403763..1404692 - 930 WP_000027727.1 formate dehydrogenase accessory protein FdhE -
NBW95_RS06875 1404689..1405324 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NBW95_RS06880 1405321..1406223 - 903 WP_000331359.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13908.18 Da        Isoelectric Point: 7.3567

>T295459 WP_000238494.1 NZ_OW704627:1403351-1403725 [Salmonella enterica subsp. enterica serovar Typhi]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9437.77 Da        Isoelectric Point: 4.4463

>AT295459 WP_001523745.1 NZ_OW704627:1403109-1403351 [Salmonella enterica subsp. enterica serovar Typhi]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CND8

Antitoxin

Source ID Structure

References