Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1096294..1097054 Replicon chromosome
Accession NZ_OW704627
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name tacT Uniprot ID Q8Z2B1
Locus tag NBW95_RS05435 Protein ID WP_000533908.1
Coordinates 1096294..1096779 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag NBW95_RS05440 Protein ID WP_000965889.1
Coordinates 1096767..1097054 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW95_RS05405 1091364..1092026 + 663 WP_000747548.1 OmpA family lipoprotein -
NBW95_RS05410 1092245..1093219 + 975 WP_000804690.1 glyoxylate/hydroxypyruvate reductase GhrB -
NBW95_RS05415 1093269..1093979 - 711 WP_000190524.1 DUF3053 domain-containing protein -
NBW95_RS05420 1094418..1094705 + 288 Protein_1048 HTH-type transcriptional regulator -
NBW95_RS05425 1094996..1095208 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NBW95_RS05430 1095384..1095923 + 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
NBW95_RS05435 1096294..1096779 - 486 WP_000533908.1 GNAT family N-acetyltransferase Toxin
NBW95_RS05440 1096767..1097054 - 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
NBW95_RS05445 1097232..1097699 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
NBW95_RS05450 1097841..1098269 - 429 Protein_1054 IS3 family transposase -
NBW95_RS05455 1098659..1100728 - 2070 WP_001291805.1 glycine--tRNA ligase subunit beta -
NBW95_RS05460 1100738..1101649 - 912 WP_001168555.1 glycine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17689.38 Da        Isoelectric Point: 9.8719

>T295457 WP_000533908.1 NZ_OW704627:c1096779-1096294 [Salmonella enterica subsp. enterica serovar Typhi]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEDAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT295457 WP_000965889.1 NZ_OW704627:c1097054-1096767 [Salmonella enterica subsp. enterica serovar Typhi]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A714MHS9

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References