Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 360872..361520 Replicon chromosome
Accession NZ_OW704627
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name cptA Uniprot ID A0A715BCB4
Locus tag NBW95_RS01730 Protein ID WP_000244762.1
Coordinates 360872..361273 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NBW95_RS01735 Protein ID WP_000351186.1
Coordinates 361254..361520 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW95_RS01710 356801..358534 - 1734 WP_000813396.1 single-stranded-DNA-specific exonuclease RecJ -
NBW95_RS01715 358540..359253 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBW95_RS01720 359277..360173 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NBW95_RS01725 360286..360807 + 522 WP_001055885.1 flavodoxin FldB -
NBW95_RS01730 360872..361273 - 402 WP_000244762.1 protein YgfX Toxin
NBW95_RS01735 361254..361520 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NBW95_RS01740 361770..362750 + 981 WP_000874170.1 tRNA-modifying protein YgfZ -
NBW95_RS01745 362866..363525 - 660 WP_000250289.1 hemolysin III family protein -
NBW95_RS01750 363689..364000 - 312 WP_001182971.1 N(4)-acetylcytidine aminohydrolase -
NBW95_RS01755 364159..365592 + 1434 WP_001230148.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15773.75 Da        Isoelectric Point: 10.7537

>T295456 WP_000244762.1 NZ_OW704627:c361273-360872 [Salmonella enterica subsp. enterica serovar Typhi]
VVLWQSDLRVSWRAQWISLLLHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPI

Download         Length: 402 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT295456 WP_000351186.1 NZ_OW704627:c361520-361254 [Salmonella enterica subsp. enterica serovar Typhi]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A715BCB4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References