Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4299491..4300139 Replicon chromosome
Accession NZ_OW704291
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name cptA Uniprot ID A0A715BCB4
Locus tag NBX00_RS21025 Protein ID WP_000244762.1
Coordinates 4299491..4299892 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NBX00_RS21030 Protein ID WP_000351186.1
Coordinates 4299873..4300139 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBX00_RS21005 4295420..4297153 - 1734 WP_000813396.1 single-stranded-DNA-specific exonuclease RecJ -
NBX00_RS21010 4297159..4297872 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBX00_RS21015 4297896..4298792 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NBX00_RS21020 4298905..4299426 + 522 WP_001055885.1 flavodoxin FldB -
NBX00_RS21025 4299491..4299892 - 402 WP_000244762.1 protein YgfX Toxin
NBX00_RS21030 4299873..4300139 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NBX00_RS21035 4300389..4301369 + 981 WP_000874170.1 tRNA-modifying protein YgfZ -
NBX00_RS21040 4301485..4302144 - 660 WP_000250289.1 hemolysin III family protein -
NBX00_RS21045 4302308..4302619 - 312 WP_001182971.1 N(4)-acetylcytidine aminohydrolase -
NBX00_RS21050 4302778..4304211 + 1434 WP_001230148.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15773.75 Da        Isoelectric Point: 10.7537

>T295453 WP_000244762.1 NZ_OW704291:c4299892-4299491 [Salmonella enterica subsp. enterica serovar Typhi]
VVLWQSDLRVSWRAQWISLLLHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPI

Download         Length: 402 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT295453 WP_000351186.1 NZ_OW704291:c4300139-4299873 [Salmonella enterica subsp. enterica serovar Typhi]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A715BCB4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References