Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4282749..4283374 Replicon chromosome
Accession NZ_OW704291
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NBX00_RS20935 Protein ID WP_000911334.1
Coordinates 4282749..4283147 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NBX00_RS20940 Protein ID WP_000557549.1
Coordinates 4283147..4283374 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBX00_RS20920 4279427..4280008 - 582 WP_001244646.1 fimbrial protein -
NBX00_RS20925 4280727..4281359 - 633 WP_000835268.1 YfdX family protein -
NBX00_RS20930 4281406..4281942 - 537 WP_001038500.1 STM3031 family outer membrane protein -
NBX00_RS20935 4282749..4283147 - 399 WP_000911334.1 tRNA(fMet)-specific endonuclease VapC Toxin
NBX00_RS20940 4283147..4283374 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NBX00_RS20945 4283551..4283802 + 252 WP_001540858.1 hypothetical protein -
NBX00_RS20950 4284077..4284883 + 807 WP_077905073.1 DUF1460 domain-containing protein -
NBX00_RS20955 4285516..4286637 - 1122 WP_000028980.1 hypothetical protein -
NBX00_RS20960 4286739..4287194 - 456 WP_223229661.1 hypothetical protein -
NBX00_RS20965 4287277..4287480 - 204 WP_000184036.1 hypothetical protein -
NBX00_RS20970 4287484..4288203 - 720 WP_000082599.1 Rha family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4273559..4290455 16896


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15091.44 Da        Isoelectric Point: 7.7785

>T295452 WP_000911334.1 NZ_OW704291:c4283147-4282749 [Salmonella enterica subsp. enterica serovar Typhi]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNFAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT295452 WP_000557549.1 NZ_OW704291:c4283374-4283147 [Salmonella enterica subsp. enterica serovar Typhi]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References