Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4129015..4129829 Replicon chromosome
Accession NZ_OW704291
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag NBX00_RS20220 Protein ID WP_000971655.1
Coordinates 4129302..4129829 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag NBX00_RS20215 Protein ID WP_000855694.1
Coordinates 4129015..4129305 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBX00_RS20195 4124907..4126595 - 1689 WP_000848103.1 type III secretion system outer membrane ring protein InvG -
NBX00_RS20200 4126592..4127242 - 651 WP_001674874.1 type III secretion system transcriptional activator InvF -
NBX00_RS20205 4127698..4128141 + 444 WP_000715096.1 SPI-1 type III secretion system invasion lipoprotein InvH -
NBX00_RS20210 4128545..4128745 + 201 Protein_3953 transposase -
NBX00_RS20215 4129015..4129305 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
NBX00_RS20220 4129302..4129829 + 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
NBX00_RS20225 4129902..4130323 - 422 Protein_3956 IS5/IS1182 family transposase -
NBX00_RS20230 4130550..4131206 + 657 WP_000420463.1 protein-serine/threonine phosphatase -
NBX00_RS20235 4131376..4131896 - 521 Protein_3958 cytoplasmic protein -
NBX00_RS20240 4132054..4134621 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4129902..4130048 146


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T295451 WP_000971655.1 NZ_OW704291:4129302-4129829 [Salmonella enterica subsp. enterica serovar Typhi]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT295451 WP_000855694.1 NZ_OW704291:4129015-4129305 [Salmonella enterica subsp. enterica serovar Typhi]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References