Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3787733..3788514 Replicon chromosome
Accession NZ_OW704291
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1M4
Locus tag NBX00_RS18695 Protein ID WP_000626103.1
Coordinates 3787733..3788224 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1M5
Locus tag NBX00_RS18700 Protein ID WP_001110456.1
Coordinates 3788221..3788514 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBX00_RS18670 3783500..3784864 - 1365 WP_000018529.1 SPI-7-type island replicative DNA helicase -
NBX00_RS18675 3784861..3785895 - 1035 WP_001195363.1 ParA family protein -
NBX00_RS18680 3786109..3786183 - 75 Protein_3658 helix-turn-helix domain-containing protein -
NBX00_RS18685 3786563..3786640 + 78 Protein_3659 porin family protein -
NBX00_RS18690 3786740..3787492 + 753 WP_001785756.1 non-specific acid phosphatase -
NBX00_RS18695 3787733..3788224 - 492 WP_000626103.1 GNAT family N-acetyltransferase Toxin
NBX00_RS18700 3788221..3788514 - 294 WP_001110456.1 DUF1778 domain-containing protein Antitoxin
NBX00_RS18705 3788831..3789053 + 223 Protein_3663 hypothetical protein -
NBX00_RS18710 3789319..3790194 + 876 WP_000921674.1 AraC family transcriptional regulator -
NBX00_RS18715 3790191..3790478 + 288 WP_001269916.1 transcriptional regulator RtsB -
NBX00_RS18720 3790501..3790717 + 217 Protein_3666 hypothetical protein -
NBX00_RS18725 3790725..3791069 + 345 WP_100680417.1 Ig-like domain-containing protein -
NBX00_RS18730 3791356..3792261 - 906 WP_001268195.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17675.47 Da        Isoelectric Point: 7.2652

>T295450 WP_000626103.1 NZ_OW704291:c3788224-3787733 [Salmonella enterica subsp. enterica serovar Typhi]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQWVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11005.67 Da        Isoelectric Point: 8.6141

>AT295450 WP_001110456.1 NZ_OW704291:c3788514-3788221 [Salmonella enterica subsp. enterica serovar Typhi]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEVLIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A718CB38

Antitoxin

Source ID Structure
AlphaFold DB A0A716NSU2

References