Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2074325..2074885 Replicon chromosome
Accession NC_021500
Organism Enterobacter sp. R4-368

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag H650_RS09745 Protein ID WP_020455099.1
Coordinates 2074574..2074885 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag H650_RS09740 Protein ID WP_020455098.1
Coordinates 2074325..2074570 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H650_RS09710 2069445..2070374 + 930 WP_020455092.1 UTP--glucose-1-phosphate uridylyltransferase GalU -
H650_RS09715 2070418..2071428 + 1011 WP_020455093.1 hypothetical protein -
H650_RS09720 2071639..2072553 + 915 WP_020455094.1 DNA-binding transcriptional regulator OxyR -
H650_RS09725 2072556..2072987 - 432 WP_020455095.1 hypothetical protein -
H650_RS09735 2073591..2074187 + 597 WP_197539472.1 nitroreductase family protein -
H650_RS09740 2074325..2074570 + 246 WP_020455098.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
H650_RS09745 2074574..2074885 + 312 WP_020455099.1 CcdB family protein Toxin
H650_RS09750 2074942..2076063 - 1122 WP_020455100.1 cupin domain-containing protein -
H650_RS09755 2076128..2077060 - 933 WP_020455101.1 LysR family transcriptional regulator -
H650_RS09760 2077164..2078231 + 1068 WP_020455102.1 SDR family oxidoreductase -
H650_RS09765 2078578..2079153 - 576 WP_020455103.1 ABATE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-102)

Antitoxin

Post-segregation antitoxin CcdA

(11-81)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11787.59 Da        Isoelectric Point: 6.4520

>T29545 WP_020455099.1 NC_021500:2074574-2074885 [Enterobacter sp. R4-368]
MQYSVYRNKSNSRDFPFLLDVQSDIIGSMNSRVVIPLCPLADYKDRRRVERLNPVLEIEGNSYLLLTHDLAGVSLAILGE
EVCSMRAQRDVIRNAMDFIFHGI

Download         Length: 312 bp

>T29545 NC_021500:2074574-2074885 [Enterobacter sp. R4-368]
ATGCAATATTCGGTTTATCGGAACAAAAGTAACAGCCGGGATTTCCCGTTTCTGCTGGATGTACAGAGCGATATTATCGG
TAGCATGAACTCGCGGGTGGTGATCCCGCTCTGCCCACTGGCGGATTACAAAGATCGCCGCCGGGTTGAGCGGTTAAATC
CGGTACTGGAGATCGAAGGGAACTCGTATTTGTTACTGACCCACGATCTTGCAGGCGTCAGCCTGGCGATTTTGGGTGAA
GAGGTTTGCAGTATGCGCGCGCAGCGCGACGTGATCCGCAACGCGATGGATTTTATTTTTCACGGGATTTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9214.35 Da        Isoelectric Point: 8.8279

>AT29545 WP_020455098.1 NC_021500:2074325-2074570 [Enterobacter sp. R4-368]
MPATAPKQRNKQNVSVTVERELLEQARKEGINLSQTLATALQGELRNLAAERWKRENAAAIADLNEFIAERGHFSDEHRK
F

Download         Length: 246 bp

>AT29545 NC_021500:2074325-2074570 [Enterobacter sp. R4-368]
ATGCCTGCTACTGCACCTAAACAGCGAAACAAGCAAAATGTCAGCGTGACCGTCGAGCGCGAGCTACTGGAACAAGCGCG
CAAAGAAGGCATCAACCTTTCGCAAACACTTGCGACCGCCTTGCAAGGTGAACTGCGCAATCTGGCAGCTGAGCGCTGGA
AGCGCGAAAATGCCGCCGCCATTGCCGATCTAAATGAATTTATTGCCGAACGCGGCCACTTCTCGGATGAACACAGGAAG
TTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References