Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3666389..3667167 Replicon chromosome
Accession NZ_OW704291
Organism Salmonella enterica subsp. enterica serovar Typhi strain BRD948

Toxin (Protein)


Gene name TacT2 Uniprot ID Q8Z1C2
Locus tag NBX00_RS18000 Protein ID WP_000622308.1
Coordinates 3666389..3666877 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID Q8Z1C3
Locus tag NBX00_RS18005 Protein ID WP_001143724.1
Coordinates 3666874..3667167 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBX00_RS17985 3662835..3665120 + 2286 WP_010989300.1 hypothetical protein -
NBX00_RS17990 3665424..3665675 + 252 WP_024131240.1 hypothetical protein -
NBX00_RS17995 3665757..3666209 + 453 WP_000434168.1 hypothetical protein -
NBX00_RS18000 3666389..3666877 - 489 WP_000622308.1 GNAT family N-acetyltransferase Toxin
NBX00_RS18005 3666874..3667167 - 294 WP_001143724.1 DUF1778 domain-containing protein Antitoxin
NBX00_RS18010 3667594..3668607 - 1014 WP_000449622.1 site-specific integrase -
NBX00_RS18015 3668771..3670360 - 1590 WP_000488995.1 TraI domain-containing protein -
NBX00_RS18020 3670344..3671855 - 1512 WP_001120833.1 UvrD-helicase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - tviB / tviC / tviD / tviE / vexA / vexB / vexC / vexD / vexE / sopE2 3654172..3786030 131858


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17538.36 Da        Isoelectric Point: 7.3252

>T295449 WP_000622308.1 NZ_OW704291:c3666877-3666389 [Salmonella enterica subsp. enterica serovar Typhi]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVTGASRTFVCCGSDSDVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLV
HA

Download         Length: 489 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10906.59 Da        Isoelectric Point: 6.3493

>AT295449 WP_001143724.1 NZ_OW704291:c3667167-3666874 [Salmonella enterica subsp. enterica serovar Typhi]
MPVANSMAMKRETLNLRIKPAERDLIDRAAKARGKNCTDFVLEAARAAAEEALIEQRIIMADPEAYQAFLIRLDQAPAPN
DALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A716G941

Antitoxin

Source ID Structure
AlphaFold DB A0A716D9M3

References