Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-RelB
Location 1665709..1666264 Replicon chromosome
Accession NZ_OW703833
Organism Bifidobacterium longum subsp. infantis isolate hadza_2261_Bf14

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NBW67_RS07595 Protein ID WP_250235216.1
Coordinates 1665941..1666264 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NBW67_RS07590 Protein ID WP_250235214.1
Coordinates 1665709..1665954 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW67_RS07565 1660899..1661084 - 186 WP_162859245.1 hypothetical protein -
NBW67_RS07570 1661523..1662209 + 687 WP_250235212.1 TetR/AcrR family transcriptional regulator -
NBW67_RS07575 1662366..1663637 + 1272 WP_143723277.1 MFS transporter -
NBW67_RS07580 1663821..1664012 - 192 WP_143723276.1 XRE family transcriptional regulator -
NBW67_RS07585 1664279..1665535 - 1257 WP_106642259.1 HipA domain-containing protein -
NBW67_RS07590 1665709..1665954 + 246 WP_250235214.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBW67_RS07595 1665941..1666264 + 324 WP_250235216.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NBW67_RS07600 1666481..1667095 - 615 WP_154050571.1 cupin domain-containing protein -
NBW67_RS07605 1667190..1668059 - 870 WP_003829104.1 class I SAM-dependent methyltransferase -
NBW67_RS07610 1668297..1668662 + 366 WP_065474609.1 YccF domain-containing protein -
NBW67_RS07615 1669206..1670471 + 1266 WP_136500160.1 Fic family protein -
NBW67_RS07620 1670569..1670724 - 156 WP_019728038.1 hypothetical protein -
NBW67_RS07625 1670942..1671240 + 299 Protein_1492 IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-56)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11874.64 Da        Isoelectric Point: 4.5781

>T295437 WP_250235216.1 NZ_OW703833:1665941-1666264 [Bifidobacterium longum subsp. infantis]
MERGEIWTLQADGYASKPRPLVIVQSDAVDRFDSVITCLLTSYDSSDIDTRVRLEPSPENGLNKVSYVMTDKIVTVDRKL
LGYQVGVVDDAAMANIGRQLMRVLGLL

Download         Length: 324 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9267.37 Da        Isoelectric Point: 4.7571

>AT295437 WP_250235214.1 NZ_OW703833:1665709-1665954 [Bifidobacterium longum subsp. infantis]
MSMQIATRVDDEQAALFKETTRQLGTTPADALRMFISAFNDYRGFPYEVRLPRNDVEPFASERDATEYASRLALRMSDGT
R

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References