Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/RelB(antitoxin)
Location 1606685..1607324 Replicon chromosome
Accession NZ_OW703833
Organism Bifidobacterium longum subsp. infantis isolate hadza_2261_Bf14

Toxin (Protein)


Gene name mazF Uniprot ID W6EZW1
Locus tag NBW67_RS07290 Protein ID WP_014484977.1
Coordinates 1606968..1607324 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NBW67_RS07285 Protein ID WP_003829235.1
Coordinates 1606685..1606981 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW67_RS07260 1601759..1602214 - 456 WP_012577916.1 Holliday junction resolvase RuvX -
NBW67_RS07265 1602223..1604901 - 2679 WP_250231665.1 alanine--tRNA ligase -
NBW67_RS07270 1605030..1605266 - 237 WP_047379873.1 hypothetical protein -
NBW67_RS07275 1605266..1605664 - 399 WP_012577919.1 DUF948 domain-containing protein -
NBW67_RS07280 1605747..1606421 - 675 WP_065456637.1 histidine phosphatase family protein -
NBW67_RS07285 1606685..1606981 + 297 WP_003829235.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBW67_RS07290 1606968..1607324 + 357 WP_014484977.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NBW67_RS07295 1607501..1608103 - 603 WP_250235166.1 transglutaminase family protein -
NBW67_RS07300 1608208..1608564 - 357 WP_038426137.1 SdpI family protein -
NBW67_RS07305 1608648..1609088 + 441 WP_250235168.1 cytidine deaminase -
NBW67_RS07310 1609271..1610053 + 783 WP_144098495.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
NBW67_RS07315 1610233..1610859 - 627 WP_007052130.1 30S ribosomal protein S4 -
NBW67_RS07320 1611058..1612050 - 993 WP_081356789.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-111)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(12-54)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13302.25 Da        Isoelectric Point: 8.9603

>T295436 WP_014484977.1 NZ_OW703833:1606968-1607324 [Bifidobacterium longum subsp. infantis]
MMKTDPRQFEIWWVPFAFPDKPGKAKNRPSVILQWDDGTRIALVTKVTGNTWRDEPGYVVLRDWQDAGLSKPSAVRCSQL
LRLPSNLFLDDGPTGRLSAYDAGRVAWAINELYPGLLA

Download         Length: 357 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10997.50 Da        Isoelectric Point: 4.2896

>AT295436 WP_003829235.1 NZ_OW703833:1606685-1606981 [Bifidobacterium longum subsp. infantis]
MMAIKEKTTISLDAQTKRDGIAILDAMGLNLSTFAEMSLRQLVRDGRLPFTPSVRPSFEKDNEGYPLFKANMDDPRIVTP
QIRDGAVILPEGWDDDED

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L7D489

Antitoxin

Source ID Structure

References