Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 1188909..1189762 Replicon chromosome
Accession NZ_OW703833
Organism Bifidobacterium longum subsp. infantis isolate hadza_2261_Bf14

Toxin (Protein)


Gene name relE Uniprot ID A0A1S2W236
Locus tag NBW67_RS05160 Protein ID WP_071477730.1
Coordinates 1189271..1189762 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q8G4I4
Locus tag NBW67_RS05155 Protein ID WP_011068030.1
Coordinates 1188909..1189271 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW67_RS05150 1186064..1188763 + 2700 WP_250235693.1 aconitate hydratase AcnA -
NBW67_RS05155 1188909..1189271 + 363 WP_011068030.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBW67_RS05160 1189271..1189762 + 492 WP_071477730.1 PIN domain-containing protein Toxin
NBW67_RS05165 1189822..1191927 - 2106 WP_250235694.1 DUF262 domain-containing protein -
NBW67_RS05170 1192016..1192657 - 642 WP_013140893.1 GNAT family N-acetyltransferase -
NBW67_RS05175 1192698..1192838 - 141 Protein_1007 LuxR C-terminal-related transcriptional regulator -
NBW67_RS05180 1193007..1193909 + 903 WP_071477732.1 Bax inhibitor-1/YccA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18344.91 Da        Isoelectric Point: 4.5590

>T295434 WP_071477730.1 NZ_OW703833:1189271-1189762 [Bifidobacterium longum subsp. infantis]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLSSSAIRREFKPNESEVENFTRSF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Download         Length: 492 bp

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 14004.05 Da        Isoelectric Point: 5.0733

>AT295434 WP_011068030.1 NZ_OW703833:1188909-1189271 [Bifidobacterium longum subsp. infantis]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDTYYNMKRAD

Download         Length: 363 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S2W236

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2W1N3

References