Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 23349..23914 Replicon chromosome
Accession NZ_OW703833
Organism Bifidobacterium longum subsp. infantis isolate hadza_2261_Bf14

Toxin (Protein)


Gene name relE Uniprot ID A0A1S2W0Z4
Locus tag NBW67_RS00080 Protein ID WP_065472908.1
Coordinates 23349..23639 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B7GSH1
Locus tag NBW67_RS00085 Protein ID WP_012576473.1
Coordinates 23636..23914 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBW67_RS00065 19213..20772 - 1560 WP_174773587.1 iron ABC transporter permease -
NBW67_RS00070 20867..21925 - 1059 WP_250235260.1 ABC transporter substrate-binding protein -
NBW67_RS00075 22057..22938 - 882 WP_250235262.1 MurR/RpiR family transcriptional regulator -
NBW67_RS00080 23349..23639 - 291 WP_065472908.1 type II toxin-antitoxin system YafQ family toxin Toxin
NBW67_RS00085 23636..23914 - 279 WP_012576473.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBW67_RS00090 24162..24623 + 462 WP_143723922.1 hypothetical protein -
NBW67_RS00095 24829..25095 - 267 Protein_18 transposase -
NBW67_RS00100 25363..26004 + 642 WP_250235264.1 hypothetical protein -
NBW67_RS00115 27338..28600 - 1263 WP_065436594.1 metallophosphoesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10925.63 Da        Isoelectric Point: 9.9583

>T295433 WP_065472908.1 NZ_OW703833:c23639-23349 [Bifidobacterium longum subsp. infantis]
MSGIRYTVKTTSRFRKDFKLARRRGLDADLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECHITPDLLLVYLIEKDVL
VLTLTRTGTHSDLFGK

Download         Length: 291 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10202.63 Da        Isoelectric Point: 6.3216

>AT295433 WP_012576473.1 NZ_OW703833:c23914-23636 [Bifidobacterium longum subsp. infantis]
MSGTTTTVNVRMNAELKKQAEELFGELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S2W0Z4

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8MHE5

References