Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1850667..1852423 Replicon chromosome
Accession NZ_OW622535
Organism Burkholderia mallei strain 34 isolate 34

Toxin (Protein)


Gene name doc Uniprot ID C4APV8
Locus tag NIU15_RS07755 Protein ID WP_004195452.1
Coordinates 1851518..1852423 (-) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q63LW2
Locus tag NIU15_RS07750 Protein ID WP_004195450.1
Coordinates 1850667..1851521 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIU15_RS07730 1845883..1847373 - 1491 WP_011204548.1 aldehyde dehydrogenase -
NIU15_RS07735 1847399..1848214 - 816 WP_004195445.1 aspartate dehydrogenase -
NIU15_RS07740 1848207..1849880 - 1674 WP_004202695.1 thiamine pyrophosphate-binding protein -
NIU15_RS07745 1849873..1850670 - 798 WP_004195447.1 SDR family oxidoreductase -
NIU15_RS07750 1850667..1851521 - 855 WP_004195450.1 IclR family transcriptional regulator Antitoxin
NIU15_RS07755 1851518..1852423 - 906 WP_004195452.1 alpha/beta fold hydrolase Toxin
NIU15_RS07760 1852440..1852967 - 528 WP_011204549.1 cupin domain-containing protein -
NIU15_RS07765 1853006..1853776 - 771 WP_004184755.1 SDR family oxidoreductase -
NIU15_RS07770 1853773..1854840 - 1068 WP_004202697.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
NIU15_RS07775 1854875..1855186 - 312 WP_004184841.1 hypothetical protein -
NIU15_RS07780 1855188..1855505 - 318 WP_004184916.1 non-heme iron oxygenase ferredoxin subunit -
NIU15_RS07785 1855940..1857028 + 1089 WP_004184835.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-284)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 30555.70 Da        Isoelectric Point: 8.7357

>T295430 WP_004195452.1 NZ_OW622535:c1852423-1851518 [Burkholderia mallei]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIQRCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP

Download         Length: 906 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31152.56 Da        Isoelectric Point: 6.8932

>AT295430 WP_004195450.1 NZ_OW622535:c1851521-1850667 [Burkholderia mallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N4FRK3

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4FRW8

References