Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-yefM/YoeB-RelB |
| Location | 368249..368759 | Replicon | chromosome |
| Accession | NZ_OW443151 | ||
| Organism | Vibrio cholerae strain CNRVC190247 isolate YE-NCPHL-18035-PI | ||
Toxin (Protein)
| Gene name | relB | Uniprot ID | A0A7Z7VK37 |
| Locus tag | OC536_RS16035 | Protein ID | WP_000098715.1 |
| Coordinates | 368496..368759 (+) | Length | 88 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A7Y3QZ95 |
| Locus tag | OC536_RS16030 | Protein ID | WP_001223794.1 |
| Coordinates | 368249..368503 (+) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OC536_RS15980 | 363308..363370 | + | 63 | Protein_360 | DUF645 family protein | - |
| OC536_RS15985 | 363342..363458 | + | 117 | WP_232510684.1 | Tfp pilus assembly protein | - |
| OC536_RS15990 | 363814..363967 | + | 154 | Protein_362 | DUF645 family protein | - |
| OC536_RS15995 | 364324..364487 | + | 164 | Protein_363 | DUF645 family protein | - |
| OC536_RS16000 (CNRVC190247_03179) | 364743..364973 | - | 231 | WP_000838533.1 | PAS factor family protein | - |
| OC536_RS16005 | 365112..365174 | + | 63 | Protein_365 | acetyltransferase | - |
| OC536_RS16010 (CNRVC190247_03180) | 365407..366534 | + | 1128 | WP_262102102.1 | ISAs1-like element IS1358 family transposase | - |
| OC536_RS16015 | 366567..366826 | + | 260 | Protein_367 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| OC536_RS16020 (CNRVC190247_03181) | 366813..367127 | + | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | - |
| OC536_RS16025 (CNRVC190247_03182) | 367266..368039 | + | 774 | WP_032471917.1 | aminoglycoside phosphotransferase family protein | - |
| OC536_RS16030 (CNRVC190247_03183) | 368249..368503 | + | 255 | WP_001223794.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| OC536_RS16035 (CNRVC190247_03184) | 368496..368759 | + | 264 | WP_000098715.1 | Txe/YoeB family addiction module toxin | Toxin |
| OC536_RS16040 | 369130..369177 | + | 48 | Protein_372 | DUF645 family protein | - |
| OC536_RS16045 | 369182..369271 | + | 90 | WP_229598405.1 | Tfp pilus assembly protein | - |
| OC536_RS16050 | 369459..369962 | + | 504 | WP_262102103.1 | hypothetical protein | - |
| OC536_RS16055 | 369969..370031 | + | 63 | Protein_375 | acetyltransferase | - |
| OC536_RS16060 (CNRVC190247_03185) | 370058..370597 | + | 540 | WP_248431594.1 | isochorismatase family protein | - |
| OC536_RS16065 (CNRVC190247_03186) | 370732..371220 | + | 489 | WP_114717217.1 | dual specificity protein phosphatase family protein | - |
| OC536_RS16070 (CNRVC190247_03187) | 371395..372267 | + | 873 | WP_000254717.1 | DUF3800 domain-containing protein | - |
| OC536_RS16075 (CNRVC190247_03188) | 372418..372741 | + | 324 | WP_000248693.1 | DUF4144 domain-containing protein | - |
| OC536_RS16080 (CNRVC190247_03189) | 372889..373362 | + | 474 | WP_153734401.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | qnrVC4 | - | 308122..375907 | 67785 | |
| - | flank | IS/Tn | - | - | 365407..366534 | 1127 | |
| - | inside | Integron | qnrVC4 | - | 308793..373362 | 64569 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Z7VK37 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Y3QZ95 |