Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 355942..356507 | Replicon | chromosome |
| Accession | NZ_OW443151 | ||
| Organism | Vibrio cholerae strain CNRVC190247 isolate YE-NCPHL-18035-PI | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HCW8 |
| Locus tag | OC536_RS15905 | Protein ID | WP_000869999.1 |
| Coordinates | 356220..356507 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | D0IIK3 |
| Locus tag | OC536_RS15900 | Protein ID | WP_000086649.1 |
| Coordinates | 355942..356223 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OC536_RS15855 | 350961..351152 | + | 192 | WP_113707167.1 | disulfide bond formation protein DsbD | - |
| OC536_RS15860 | 351170..351406 | + | 237 | WP_032477346.1 | DUF3709 domain-containing protein | - |
| OC536_RS15865 | 351797..351979 | + | 183 | WP_032477360.1 | DUF645 family protein | - |
| OC536_RS15870 (CNRVC190247_03163) | 352631..352951 | + | 321 | WP_000248687.1 | DUF4144 domain-containing protein | - |
| OC536_RS15875 (CNRVC190247_03164) | 353107..353493 | + | 387 | WP_029628680.1 | MmcQ/YjbR family DNA-binding protein | - |
| OC536_RS15880 (CNRVC190247_03165) | 353635..353994 | + | 360 | WP_001900224.1 | hypothetical protein | - |
| OC536_RS15885 (CNRVC190247_03166) | 354144..354440 | + | 297 | WP_001069046.1 | hypothetical protein | - |
| OC536_RS15890 (CNRVC190247_03167) | 355126..355413 | + | 288 | WP_032477340.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| OC536_RS15895 (CNRVC190247_03168) | 355424..355741 | + | 318 | WP_032477342.1 | HigA family addiction module antitoxin | - |
| OC536_RS15900 (CNRVC190247_03169) | 355942..356223 | + | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| OC536_RS15905 (CNRVC190247_03170) | 356220..356507 | + | 288 | WP_000869999.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| OC536_RS15910 (CNRVC190247_03171) | 356662..357159 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| OC536_RS15915 (CNRVC190247_03172) | 357156..357428 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| OC536_RS15920 | 357817..357957 | + | 141 | WP_001952202.1 | DUF645 family protein | - |
| OC536_RS15925 (CNRVC190247_03173) | 358204..358542 | + | 339 | WP_050503336.1 | hypothetical protein | - |
| OC536_RS15930 (CNRVC190247_03174) | 358709..359245 | + | 537 | WP_000469478.1 | GNAT family protein | - |
| OC536_RS15935 (CNRVC190247_03175) | 359416..359778 | + | 363 | WP_000391481.1 | DUF6232 family protein | - |
| OC536_RS15940 (CNRVC190247_03177) | 359965..360201 | - | 237 | WP_000772125.1 | RNA-binding protein | - |
| OC536_RS15945 (CNRVC190247_03178) | 360437..360742 | + | 306 | WP_000064427.1 | hypothetical protein | - |
| OC536_RS15950 | 360799..360914 | + | 116 | Protein_354 | acetyltransferase | - |
| OC536_RS15955 | 361083..361188 | + | 106 | Protein_355 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | qnrVC4 | - | 308122..375907 | 67785 | |
| - | inside | Integron | qnrVC4 | - | 308793..373362 | 64569 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3AEF1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UIW4 |