295405

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2286375..2288200 Replicon chromosome
Accession NZ_OW443150
Organism Vibrio cholerae strain CNRVC190247 isolate YE-NCPHL-18035-PI

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OC536_RS10360 Protein ID WP_000391999.1
Coordinates 2286375..2287736 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OC536_RS10365 Protein ID WP_032476747.1
Coordinates 2287733..2288200 (+) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OC536_RS10330 (CNRVC190247_02077) 2281602..2282030 + 429 WP_032476753.1 DUF2787 domain-containing protein -
OC536_RS10335 (CNRVC190247_02078) 2282081..2282527 + 447 WP_032476752.1 DUF2787 domain-containing protein -
OC536_RS10340 (CNRVC190247_02079) 2282633..2283619 + 987 WP_032476751.1 GTPase family protein -
OC536_RS10345 (CNRVC190247_02080) 2283654..2284295 - 642 WP_032476750.1 inovirus Gp2 family protein -
OC536_RS10350 (CNRVC190247_02081) 2284587..2285432 + 846 WP_032476749.1 hypothetical protein -
OC536_RS10355 (CNRVC190247_02082) 2285547..2285747 - 201 WP_032476748.1 AlpA family transcriptional regulator -
OC536_RS10360 (CNRVC190247_02083) 2286375..2287736 + 1362 WP_000391999.1 type II toxin-antitoxin system HipA family toxin Toxin
OC536_RS10365 (CNRVC190247_02084) 2287733..2288200 + 468 WP_032476747.1 helix-turn-helix transcriptional regulator Antitoxin
OC536_RS10370 (CNRVC190247_02085) 2288782..2291922 - 3141 WP_032476746.1 DEAD/DEAH box helicase -
OC536_RS10375 (CNRVC190247_02086) 2292349..2293032 + 684 WP_000841479.1 VC0807 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-367)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51341.23 Da        Isoelectric Point: 4.9109

>T295405 WP_000391999.1 NZ_OW443150:2286375-2287736 [Vibrio cholerae]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPGGIPRTTKWKAPLEFGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17019.55 Da        Isoelectric Point: 10.8420

>AT295405 WP_032476747.1 NZ_OW443150:2287733-2288200 [Vibrio cholerae]
MKPSNKESVQDTVARLRANRNQQQPKVGKSATHSSKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGKDG

Download         Length: 468 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References