Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3147528..3148155 Replicon chromosome
Accession NZ_OW235315
Organism Tepidibacter sp. 8C15b

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M2214_RS15320 Protein ID WP_248480679.1
Coordinates 3147528..3147890 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag M2214_RS15325 Protein ID WP_248484887.1
Coordinates 3147883..3148155 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2214_RS15300 (T8CH_3136) 3142894..3143637 - 744 WP_248480671.1 WecB/TagA/CpsF family glycosyltransferase -
M2214_RS15305 (T8CH_3137) 3143624..3144748 - 1125 WP_248480673.1 polysaccharide pyruvyl transferase CsaB -
M2214_RS15310 (T8CH_3138) 3144741..3146801 - 2061 WP_248480675.1 DUF5693 family protein -
M2214_RS15315 (T8CH_3139) 3146857..3147369 - 513 WP_248480677.1 hypothetical protein -
M2214_RS15320 (T8CH_3140) 3147528..3147890 - 363 WP_248480679.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M2214_RS15325 (T8CH_3141) 3147883..3148155 - 273 WP_248484887.1 ribbon-helix-helix protein, CopG family Antitoxin
M2214_RS15330 (T8CH_3142) 3148197..3149357 - 1161 WP_248480681.1 alanine racemase -
M2214_RS15335 (T8CH_3143) 3149377..3149961 - 585 WP_248480683.1 germination lipoprotein GerS -
M2214_RS15340 (T8CH_3144) 3149979..3150428 - 450 WP_248480685.1 CBS domain-containing protein -
M2214_RS15345 (T8CH_3145) 3150431..3150817 - 387 WP_248480687.1 holo-ACP synthase -
M2214_RS15350 (T8CH_3146) 3150912..3151526 - 615 WP_248480689.1 hypothetical protein -
M2214_RS15355 (T8CH_3147) 3151694..3152626 + 933 WP_248480691.1 hypothetical protein -
M2214_RS15360 (T8CH_3148) 3152639..3153034 - 396 WP_248480699.1 ATP synthase F1 subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(8-42)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13365.35 Da        Isoelectric Point: 5.8750

>T295381 WP_248480679.1 NZ_OW235315:c3147890-3147528 [Tepidibacter sp. 8C15b]
VNNNLEIKRGDIFYGDLSPVIGSEQGGVRPVLIIQNDIGNKYSPTVIIAAITSQINKAKLPTHIEINANDYGLNRDSVVL
LEQVRTIDKKRLREKIGSFDNDMMKKVDEGLQISLGLFEI

Download         Length: 363 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10239.05 Da        Isoelectric Point: 10.0312

>AT295381 WP_248484887.1 NZ_OW235315:c3148155-3147883 [Tepidibacter sp. 8C15b]
MGKKKIVVSLPNNLLSEVDKIVKVENKNRSEFIKEAMNLYLREKRKVRTRESMIKGYREMGVINLALAEMGLSMDMSSLT
GYEGKIAEGE

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References