295377

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3993703..3994346 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag MR179_RS18815 Protein ID WP_003401566.1
Coordinates 3993703..3994128 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag MR179_RS18820 Protein ID WP_003401563.1
Coordinates 3994125..3994346 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS18805 3992030..3992938 - 909 WP_030022343.1 protochlorophyllide reductase -
MR179_RS18810 3992935..3993567 - 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
MR179_RS18815 3993703..3994128 - 426 WP_003401566.1 PIN domain nuclease Toxin
MR179_RS18820 3994125..3994346 - 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
MR179_RS18825 3994394..3994696 - 303 WP_003401560.1 toxin-antitoxin system toxin -
MR179_RS18830 3994693..3994920 - 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
MR179_RS18835 3995063..3996838 - 1776 WP_010886074.1 PE family protein -
MR179_RS18840 3997017..3998414 + 1398 WP_003401544.1 sulfatase -
MR179_RS18845 3998424..3999227 + 804 WP_003401540.1 Stf0 family sulphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T295377 WP_003401566.1 NZ_OW052571:c3994128-3993703 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT295377 WP_003401563.1 NZ_OW052571:c3994346-3994125 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
AlphaFold DB A0A829CG48

References