Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 3912954..3913965 | Replicon | chromosome |
| Accession | NZ_OW052571 | ||
| Organism | Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | L7N5R2 |
| Locus tag | MR179_RS18485 | Protein ID | WP_003401859.1 |
| Coordinates | 3913372..3913965 (+) | Length | 198 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | O53702 |
| Locus tag | MR179_RS18480 | Protein ID | WP_003401860.1 |
| Coordinates | 3912954..3913343 (+) | Length | 130 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MR179_RS18455 | 3908802..3909557 | + | 756 | WP_003401865.1 | XdhC family protein | - |
| MR179_RS18460 | 3909554..3910147 | + | 594 | WP_003401864.1 | NTP transferase domain-containing protein | - |
| MR179_RS18465 | 3910144..3911040 | + | 897 | WP_003898418.1 | MoxR family ATPase | - |
| MR179_RS18470 | 3911054..3911656 | + | 603 | WP_003898417.1 | SRPBCC family protein | - |
| MR179_RS18475 | 3911662..3912873 | + | 1212 | WP_003906353.1 | VWA domain-containing protein | - |
| MR179_RS18480 | 3912954..3913343 | + | 390 | WP_003401860.1 | hypothetical protein | Antitoxin |
| MR179_RS18485 | 3913372..3913965 | + | 594 | WP_003401859.1 | zeta toxin family protein | Toxin |
| MR179_RS18490 | 3913990..3915120 | + | 1131 | WP_003401858.1 | glycoside hydrolase family 76 protein | - |
| MR179_RS18495 | 3915109..3915792 | - | 684 | WP_003401857.1 | VTT domain-containing protein | - |
| MR179_RS18500 | 3915888..3916922 | + | 1035 | WP_003401856.1 | class II fructose-bisphosphate aldolase | - |
| MR179_RS18505 | 3916934..3918316 | - | 1383 | WP_242364756.1 | magnesium transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 198 a.a. Molecular weight: 21344.53 Da Isoelectric Point: 10.5018
>T295376 WP_003401859.1 NZ_OW052571:3913372-3913965 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA
Download Length: 594 bp
Antitoxin
Download Length: 130 a.a. Molecular weight: 13648.21 Da Isoelectric Point: 6.0829
>AT295376 WP_003401860.1 NZ_OW052571:3912954-3913343 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP
Download Length: 390 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BRU8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BRT0 |