295375

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 3716005..3716681 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag MR179_RS17520 Protein ID WP_003898500.1
Coordinates 3716268..3716681 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag MR179_RS17515 Protein ID WP_003402915.1
Coordinates 3716005..3716271 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS17500 3711439..3712419 - 981 WP_003402923.1 o-succinylbenzoate synthase -
MR179_RS17505 3712416..3714020 - 1605 WP_003402920.1 amidohydrolase -
MR179_RS17510 3714098..3715813 + 1716 WP_003402917.1 fatty-acid--CoA ligase FadD8 -
MR179_RS17515 3716005..3716271 + 267 WP_003402915.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
MR179_RS17520 3716268..3716681 + 414 WP_003898500.1 type II toxin-antitoxin system VapC family toxin Toxin
MR179_RS17525 3716995..3717897 + 903 WP_003915439.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
MR179_RS17530 3717993..3718877 + 885 WP_003402909.1 SDR family oxidoreductase -
MR179_RS17535 3718940..3719326 + 387 WP_003402907.1 VOC family protein -
MR179_RS17540 3719446..3720699 + 1254 WP_003911224.1 inorganic phosphate transporter -
MR179_RS17545 3720696..3720974 + 279 WP_003402901.1 hypothetical protein -
MR179_RS17550 3721034..3721336 + 303 WP_003402896.1 DUF3349 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T295375 WP_003898500.1 NZ_OW052571:3716268-3716681 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT295375 WP_003402915.1 NZ_OW052571:3716005-3716271 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References