295374

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3678589..3679208 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID O53779
Locus tag MR179_RS17350 Protein ID WP_003403047.1
Coordinates 3678589..3678996 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O53778
Locus tag MR179_RS17355 Protein ID WP_003403039.1
Coordinates 3678993..3679208 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS17340 3675056..3677689 - 2634 WP_003403055.1 GH92 family glycosyl hydrolase -
MR179_RS17345 3677843..3678529 + 687 WP_003403052.1 LpqN/LpqT family lipoprotein -
MR179_RS17350 3678589..3678996 - 408 WP_003403047.1 type II toxin-antitoxin system toxin ribonuclease C26 Toxin
MR179_RS17355 3678993..3679208 - 216 WP_003403039.1 type II toxin-antitoxin system antitoxin VapB26 Antitoxin
MR179_RS17360 3679302..3679793 + 492 WP_003403017.1 mycobacterial cell wall protein Rv0580c -
MR179_RS17365 3679922..3680680 - 759 WP_003898511.1 Mut7-C RNAse domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14471.43 Da        Isoelectric Point: 4.4493

>T295374 WP_003403047.1 NZ_OW052571:c3678996-3678589 [Mycobacterium tuberculosis]
VIIDTSALLAYFDAAEPDHAAVSECIDSSADALVVSPYVVAELDYLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQ
AARIVTKYQDQRIGIADAANVVLADRYRTRTILTLDRRHFSALRPIGGGRFTVIP

Download         Length: 408 bp

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7572.66 Da        Isoelectric Point: 10.5454

>AT295374 WP_003403039.1 NZ_OW052571:c3679208-3678993 [Mycobacterium tuberculosis]
VDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKPPPRGGLYAGSEPIARRVDELLAGFGER

Download         Length: 216 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5X3T

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSA2

References