295373

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 3661433..3662079 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag MR179_RS17285 Protein ID WP_003403122.1
Coordinates 3661687..3662079 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag MR179_RS17280 Protein ID WP_003403125.1
Coordinates 3661433..3661690 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS17245 3656751..3657062 - 312 WP_003403164.1 hypothetical protein -
MR179_RS17250 3657185..3657880 + 696 WP_003918099.1 two-component system response regulator TcrA -
MR179_RS17255 3657864..3658394 + 531 WP_003917320.1 two component system sensor kinase HK2 -
MR179_RS17260 3658508..3659014 + 507 WP_003900973.1 two component system sensor kinase HK1 -
MR179_RS17265 3659118..3659354 + 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 -
MR179_RS17270 3659351..3659764 + 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
MR179_RS17275 3660015..3661250 + 1236 WP_003403128.1 ATP-binding protein -
MR179_RS17280 3661433..3661690 + 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
MR179_RS17285 3661687..3662079 + 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
MR179_RS17290 3662131..3663681 - 1551 WP_003403119.1 MlaD family protein -
MR179_RS17295 3663686..3664828 - 1143 WP_003911253.1 virulence factor Mce family protein -
MR179_RS17300 3664891..3666417 - 1527 WP_003403112.1 virulence factor Mce family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T295373 WP_003403122.1 NZ_OW052571:3661687-3662079 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT295373 WP_003403125.1 NZ_OW052571:3661433-3661690 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References