Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3653031..3653674 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag MR179_RS17215 Protein ID WP_003403187.1
Coordinates 3653031..3653432 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag MR179_RS17220 Protein ID WP_003403184.1
Coordinates 3653429..3653674 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS17190 3649989..3650594 - 606 WP_003898526.1 hypothetical protein -
MR179_RS17195 3650736..3650957 + 222 WP_003898525.1 DUF4926 domain-containing protein -
MR179_RS17200 3651009..3652166 + 1158 WP_003898524.1 hypothetical protein -
MR179_RS17205 3652246..3652443 + 198 WP_003403191.1 hypothetical protein -
MR179_RS17210 3652861..3653040 - 180 Protein_3399 hypothetical protein -
MR179_RS17215 3653031..3653432 - 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
MR179_RS17220 3653429..3653674 - 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MR179_RS17225 3653719..3654189 - 471 WP_003898523.1 hypothetical protein -
MR179_RS17230 3654192..3654902 - 711 Protein_3403 IS607 family element RNA-guided endonuclease TnpB -
MR179_RS17235 3654904..3655488 - 585 WP_003403171.1 IS607-like element IS1536 family transposase -
MR179_RS17240 3655729..3656679 - 951 WP_003900184.1 DUF1259 domain-containing protein -
MR179_RS17245 3656751..3657062 - 312 WP_003403164.1 hypothetical protein -
MR179_RS17250 3657185..3657880 + 696 WP_003918099.1 two-component system response regulator TcrA -
MR179_RS17255 3657864..3658394 + 531 WP_003917320.1 two component system sensor kinase HK2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T295371 WP_003403187.1 NZ_OW052571:c3653432-3653031 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT295371 WP_003403184.1 NZ_OW052571:c3653674-3653429 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References