Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3645511..3646136 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag MR179_RS17165 Protein ID WP_003403218.1
Coordinates 3645511..3645912 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag MR179_RS17170 Protein ID WP_003403213.1
Coordinates 3645909..3646136 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS17140 3640601..3641548 - 948 WP_003403232.1 DUF732 domain-containing protein -
MR179_RS17145 3641652..3642716 - 1065 WP_003898532.1 zinc ribbon domain-containing protein -
MR179_RS17150 3643111..3644202 - 1092 WP_003906403.1 galactokinase -
MR179_RS17155 3644199..3645280 - 1082 Protein_3388 galactose-1-phosphate uridylyltransferase -
MR179_RS17160 3645299..3645382 - 84 Protein_3389 galactose-1-phosphate uridylyltransferase -
MR179_RS17165 3645511..3645912 - 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
MR179_RS17170 3645909..3646136 - 228 WP_003403213.1 antitoxin VapB29 Antitoxin
MR179_RS17175 3646331..3646573 - 243 WP_003403210.1 hypothetical protein -
MR179_RS17180 3646570..3647319 - 750 WP_003898528.1 hypothetical protein -
MR179_RS17185 3647403..3649970 + 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
MR179_RS17190 3649989..3650594 - 606 WP_003898526.1 hypothetical protein -
MR179_RS17195 3650736..3650957 + 222 WP_003898525.1 DUF4926 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T295370 WP_003403218.1 NZ_OW052571:c3645912-3645511 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT295370 WP_003403213.1 NZ_OW052571:c3646136-3645909 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References