295369

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3639859..3640508 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag MR179_RS17130 Protein ID WP_003403236.1
Coordinates 3639859..3640254 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag MR179_RS17135 Protein ID WP_003403235.1
Coordinates 3640254..3640508 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS17105 3635186..3636913 + 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -
MR179_RS17110 3637006..3638157 + 1152 WP_030023880.1 FIST N-terminal domain-containing protein -
MR179_RS17115 3638229..3638636 - 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
MR179_RS17120 3638633..3638893 - 261 WP_242364750.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR179_RS17125 3639025..3639765 + 741 WP_003403239.1 TVP38/TMEM64 family protein -
MR179_RS17130 3639859..3640254 - 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
MR179_RS17135 3640254..3640508 - 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
MR179_RS17140 3640601..3641548 - 948 WP_003403232.1 DUF732 domain-containing protein -
MR179_RS17145 3641652..3642716 - 1065 WP_003898532.1 zinc ribbon domain-containing protein -
MR179_RS17150 3643111..3644202 - 1092 WP_003906403.1 galactokinase -
MR179_RS17155 3644199..3645280 - 1082 Protein_3388 galactose-1-phosphate uridylyltransferase -
MR179_RS17160 3645299..3645382 - 84 Protein_3389 galactose-1-phosphate uridylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T295369 WP_003403236.1 NZ_OW052571:c3640254-3639859 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT295369 WP_003403235.1 NZ_OW052571:c3640508-3640254 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC2

References