295368

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 3638229..3638893 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P96917
Locus tag MR179_RS17115 Protein ID WP_003403246.1
Coordinates 3638229..3638636 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MR179_RS17120 Protein ID WP_242364750.1
Coordinates 3638633..3638893 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS17105 3635186..3636913 + 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -
MR179_RS17110 3637006..3638157 + 1152 WP_030023880.1 FIST N-terminal domain-containing protein -
MR179_RS17115 3638229..3638636 - 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin Toxin
MR179_RS17120 3638633..3638893 - 261 WP_242364750.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MR179_RS17125 3639025..3639765 + 741 WP_003403239.1 TVP38/TMEM64 family protein -
MR179_RS17130 3639859..3640254 - 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 -
MR179_RS17135 3640254..3640508 - 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 -
MR179_RS17140 3640601..3641548 - 948 WP_003403232.1 DUF732 domain-containing protein -
MR179_RS17145 3641652..3642716 - 1065 WP_003898532.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-57)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14376.37 Da        Isoelectric Point: 4.3568

>T295368 WP_003403246.1 NZ_OW052571:c3638636-3638229 [Mycobacterium tuberculosis]
VSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELRVGVLAAATTDIRAQRLATLESVADMETLPVDDDAAR
MWARLRIHLAESGRRVRINDLWIAAVAASRALPVITQDDDFAALDGAASVEIIRV

Download         Length: 408 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9564.91 Da        Isoelectric Point: 11.7137

>AT295368 WP_242364750.1 NZ_OW052571:c3638893-3638633 [Mycobacterium tuberculosis]
MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPRRRRWLSKTEFLSRLRGAQADPGLRNDLAVLAGDTTE
DLEPIR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3DBO

Antitoxin

Source ID Structure

References