295367

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3603301..3603934 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag MR179_RS16945 Protein ID WP_003403365.1
Coordinates 3603551..3603934 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag MR179_RS16940 Protein ID WP_003403368.1
Coordinates 3603301..3603456 (+) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS16910 3598418..3600781 - 2364 WP_003898547.1 arylsulfatase AtsD -
MR179_RS16915 3600895..3601149 + 255 WP_003911263.1 antitoxin VapB7 -
MR179_RS16920 3601146..3601583 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
MR179_RS16925 3601693..3601938 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
MR179_RS16930 3601925..3602233 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
MR179_RS16935 3602509..3603225 + 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
MR179_RS16940 3603301..3603456 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MR179_RS16945 3603551..3603934 + 384 WP_003403365.1 ribonuclease VapC6 Toxin
MR179_RS16950 3604322..3605332 - 1011 WP_003911248.1 ABC transporter ATP-binding protein -
MR179_RS16955 3605413..3606918 - 1506 WP_003403360.1 carotenoid cleavage oxygenase -
MR179_RS16960 3606989..3607684 + 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
MR179_RS16965 3607677..3608069 - 393 WP_003403353.1 50S ribosomal protein L7/L12 -
MR179_RS16970 3608106..3608642 - 537 WP_003403341.1 50S ribosomal protein L10 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T295367 WP_003403365.1 NZ_OW052571:3603551-3603934 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT295367 WP_003403368.1 NZ_OW052571:3603301-3603456 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References