295362

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 3339883..3340502 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag MR179_RS15595 Protein ID WP_003404726.1
Coordinates 3339883..3340317 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag MR179_RS15600 Protein ID WP_003898641.1
Coordinates 3340323..3340502 (-) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS15570 3335218..3336456 + 1239 WP_003404744.1 acetyl-CoA acetyltransferase -
MR179_RS15575 3336458..3337966 + 1509 WP_003404742.1 carotenoid oxygenase family protein -
MR179_RS15580 3338133..3338363 + 231 WP_003898642.1 hypothetical protein -
MR179_RS15585 3338498..3338947 - 450 WP_003404738.1 hypothetical protein -
MR179_RS15590 3339012..3339785 - 774 WP_003404735.1 VOC family protein -
MR179_RS15595 3339883..3340317 - 435 WP_003404726.1 SRPBCC family protein Toxin
MR179_RS15600 3340323..3340502 - 180 WP_003898641.1 antitoxin Antitoxin
MR179_RS15605 3340628..3340786 - 159 WP_003404720.1 hypothetical protein -
MR179_RS15610 3341059..3343452 - 2394 WP_242364749.1 cation-translocating P-type ATPase -
MR179_RS15615 3343449..3345029 - 1581 WP_003909313.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T295362 WP_003404726.1 NZ_OW052571:c3340317-3339883 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT295362 WP_003898641.1 NZ_OW052571:c3340502-3340323 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References