295359

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3123843..3124474 Replicon chromosome
Accession NZ_OW052571
Organism Mycobacterium tuberculosis strain Lineage 4.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID P9WIH8
Locus tag MR179_RS14540 Protein ID WP_003898728.1
Coordinates 3124163..3124474 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag MR179_RS14535 Protein ID WP_003405836.1
Coordinates 3123843..3124163 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR179_RS14510 3119039..3119677 + 639 WP_003898730.1 lipid droplet-associated protein -
MR179_RS14515 3119674..3120921 + 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
MR179_RS14520 3120911..3121168 + 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
MR179_RS14525 3121178..3122290 + 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
MR179_RS14530 3122297..3123833 - 1537 Protein_2874 carboxylesterase/lipase family protein -
MR179_RS14535 3123843..3124163 + 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
MR179_RS14540 3124163..3124474 + 312 WP_003898728.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
MR179_RS14545 3124586..3125743 + 1158 WP_003898727.1 AI-2E family transporter -
MR179_RS14550 3125750..3126394 - 645 WP_003915494.1 DUF4245 domain-containing protein -
MR179_RS14555 3126450..3127538 + 1089 WP_003898726.1 class II fructose-bisphosphatase -
MR179_RS14560 3127569..3128993 + 1425 WP_030026248.1 class II fumarate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11049.76 Da        Isoelectric Point: 4.9371

>T295359 WP_003898728.1 NZ_OW052571:3124163-3124474 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNTQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT295359 WP_003405836.1 NZ_OW052571:3123843-3124163 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CCA
PDB 5UCT

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References